Key Publications

• Phosphorylation of the unique C-terminal tail of the alpha isoform of the scaffold protein SH2B1 controls the ability of SH2B1α to enhance nerve growth factor function.

Joe, R. M., A. Flores, M. E. Doche, J. M. Cline, E. S. Clutter, P. B. Vander, H. Reidel, L. S. Argetsinger, C. Carter-Su. Mol Cell Biol. 38:e00277-17. (2017). [PubMed]

• Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.

Pearce, L. R.#, R. Joe#, M. E. Doche, H.-W. Su, J. M. Keogh, E. Henning, L. S. Argetsinger, E. G. Bochukova, J. M. Cline, S. Garg, S. Saeed, S. Shoelson, S. O’Rahilly, I. Barroso, L. Rui, I. S. Farooqi⁺, and C. Carter-Su⁺. Endocrinology 155:3219-3226 (2014) (#, + authors contributed equally). [PubMed]

• Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motility.

Su, H-W, N. J. Lanning, D. L. Morris, L. S. Argetsinger, C. N. Lumeng, and C. Carter-Su. J. Cell Sci. 126:1733-1743 (2013). [PubMed]

• Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

Doche, M.E.#, E. G. Bochukova#, H.-W Su, L. Pearce, J. M. Keogh, E. Henning, J. M. Cline, A. Dale, T. Cheetham, I. Barroso, L. S. Argetsinger, S. O-Rahilly, L. Rui, C. Carter-Su⁺, I. S. Farooqi⁺. J. Clin. Invest. 122:4732-4736 (2012) (#, + authors contributed equally). [PubMed]

• Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes.

Maures, T.J., L. Chen, and C. Carter-Su. Mol. Endocrinol. 23:1077-1091 (2009). [PubMed]

• SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.

Chen, L.#, T. J. Maures#, H. Jin, J. S. Huo, S. A. Rabbani, J. Schwartz, and C. Carter-Su. Mol. Endocrinol. 22:454-476 (2008) (#Authors contributed equally). [PubMed]

• SH2-B is required for nerve growth factor-induced neuronal differentiation.

Rui, L., J. Herrington and C. Carter-Su. J. Biol. Chem. 274:10590-10594 (1999). [PubMed]

• Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.

Argetsinger, L. S.#, G. S. Campbell#, X. Yang, B. A. Witthuhn, O. Silvennoinen, J. N. Ihle and C. Carter-Su. Cell 74:237-244 (1993) (#Authors contributed equally). [PubMed]